Funding period: January 2025 to December 2027
Funding amount: € 397,000
Prof. Min Ae Lee-Kirsch, head of the Molecular Paediatrics Research Group at the University Hospital Carl Gustav Carus in Dresden, and her team will investigate the mechanisms of rare gene mutations that lead to malfunctions in the interferon signalling pathway and trigger severe disease symptoms. They will use innovative methods such as single-cell transcriptomics and CRISPR-based gene editing to understand the causes of the disease in order to make more precise diagnoses and develop individualised therapies.
Alliance4Rare research: translational, interdisciplinary, multi-site
A real hope for many families, as Prof Dr Annette Grüters-Kieslich, Scientific Director of Alliance4Rare, emphasises: “This project has the potential to fundamentally improve the lives of children with rare and difficult-to-treat immune diseases. In addition, the research findings could be groundbreaking not only for rare diseases, but also for more common forms of immune dysregulation.
In line with the Alliance4Rare network concept, the Dresden researchers will work together with colleagues from Berlin and Freiburg on an interdisciplinary and cross-location basis. In this way, scientific findings can be translated into clinical application as quickly as possible and benefit the children.
We would like to thank the Friede Springer Foundation for their generous support in funding this excellent research and the team led by Min Ae Lee-Kirsch for their great work, which gives hope.
Foto: DIGS-BB
